[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 13, Issue 4 (Winter 2013) ::
J Ardabil Univ Med Sci 2013, 13(4): 359-370 Back to browse issues page
Effects of Inulin on Lipid Profile, Inflammation and Blood Pressure in Women with Type 2 Diabetes: A Randomized Controlled Trial
Bahram Pourghassem Gargari , Parvin Dehghan , Elham Mirtaheri , Akbar Aliasgarzadeh
Abstract:   (7254 Views)

  Background & Objectives: Diabetes mellitus is a metabolic disease characterized by hyperglycemia together with biochemical alterations of lipid profile, insulin resistance and inflammation . Considering the high prevalence of hypertension, dyslipidemia and inflammation in type 2 diabetic patients, the aim of the present study was to investigate the effects of inulin on lipid profile, inflammation and blood pressure in women with type 2 diabetes.

  Methods: In this controlled, randomized clinical trial, 49 women with type 2 diabetes (fiber intake<30 g/d, BMI=25-35 kg/m2) were assigned to one of two groups. Experimental group (n=24) received 10 g/d inulin and control group (n=25) received 10 g/d maltodextrin for 8 weeks. Dietary intakes, anthropometric measurements, blood pressure, serum lipids and hs-CRP concentrations were measured at the baseline and at the end of the study. Data were analyzed using SPSS software (verision11.5). Paired, independent t-tests and ANCOVA were used to compare quantitative variables.

  Results: At the end of study, there was a significant decrease in systolic blood pressure (from 135.7 ± 16.2 to 125.9 ± 7.9 mmHg), total cholesterol ( from 192.5 ± 42.8 to 171.0 ± 39.7 mg/dl), triglyceride ( from 223.3 ± 84.2 to 169.9 ± 65.6 mg/dl) and hs-CRP ( from 7.9 ± 3.0 to 5.3 ± 3.0 mg/l) in inulin group compared with the maltodextrin group (p > 0.04 ). Changes in diastolic blood pressures, LDL-c and HDL-c were not significant in inulin group compared with the maltodextrin group. A significant decrease in systolic, diastolic blood pressures, total cholesterol, triglyceride, LDL-c, hs-CRP and significant increase in HDL-c were observed in inulin group compared to baseline.

  Conclusions: Inulin supplementation may improve lipid profile, hs-CRP and blood pressure in women with type 2 diabetes.

Keywords: Inulin; Type 2 Diabetes; Blood Pressure; Serum Lipids; hs-CRP
Full-Text [PDF 216 kb]   (1541 Downloads)    
Type of Study: article | Subject: Special
Received: 2012/09/27 | Accepted: 2013/04/9 | Published: 2013/12/22
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Pourghassem Gargari B, Dehghan P, Mirtaheri E, Aliasgarzadeh A. Effects of Inulin on Lipid Profile, Inflammation and Blood Pressure in Women with Type 2 Diabetes: A Randomized Controlled Trial. J Ardabil Univ Med Sci. 2013; 13 (4) :359-370
URL: http://jarums.arums.ac.ir/article-1-26-en.html


Volume 13, Issue 4 (Winter 2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.1 seconds with 31 queries by YEKTAWEB 3767