:: Volume 11, Issue 1 (spring 2011) ::
J Ardabil Univ Med Sci 2011, 11(1): 86-94 Back to browse issues page
Assessment of the frequency of Extended Spectrum Beta Lactamases Producing Escherichia coli Isolated from Urinary Tract Infections and its Antibiotic Resistance Pattern in Kermanshah
Parviz Mohajeri , Babak Izadi, Mansour Rezai, Badie Falahi, Hosna Khademi, Roya Ebrahimi
Abstract:   (6929 Views)

  Background & Objectives: Nowadays, appearance of ESBL producing bacteria is medical problem in the treatment of infections. Uropathogenic Escherichia coli like many other bacteria can produce these types of enzymes. T he assessment of the ESBL production by clinical isolates is not done routinely in laboratories. The aim of this study was to determine the prevalence of ESBL producing E.coli and its antibiotic resistance pattern in Kermanshah.

  Methods: This cross - sectional study was done on 200 Uropathogenic E. coli strains isolated from people in Kermanshah. Sensitivity of isolates to different antibiotics was determined by disk diffusion test and ESBL production was assessed by DDST method.

  Results: The E. coli strains showed high susceptibility to imipenem (100%), amikacin (97%), nitrofurantoin (95.5%), gentamicin (85%), cefepime (75%), ceftazidime (74%), ofloxacin (73.5%), ciprofloxacin, ceftriaxone and aztreonam (71%) and cefotaxime (70%) respectively. The highest resistance was seen to ampicillin (77%), carbenicillin (76%), pipracillin (74%) and SXT (62.5% ). Resistance rate to third generation cephalosporins was 63-75%. Fifty seven isolates (27%) were ESBL producers and 47 isolates (87%) produced all four types of ESBL enzymes.

  Conclusion: There are some similarities and differences in the antibiotic resistance pattern and ESBL production among the isolates in different areas of Iran and other countries. Identification of ESBL producing bacteria and determining its antimicrobial resistance pattern are recommended to effective treatment of infections.

Keywords: E. coli; Urinary Tract Infection; Antibiotic Resistance Pattern; ESBL; Kermanshah
Full-Text [PDF 288 kb]   (4327 Downloads)    
Type of Study: article | Subject: Special
Received: 2010/10/25 | Accepted: 2011/03/21 | Published: 2011/04/5


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Volume 11, Issue 1 (spring 2011) Back to browse issues page