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:: Volume 18, Issue 2 (summer 2018) ::
J Ardabil Univ Med Sci 2018, 18(2): 204-214 Back to browse issues page
Effects of Pentoxifylline on Nitric Oxide Levels and Histopathology of Pancreas in Diabetic Mice
Farin Malekifard , Norooz Delirezh , Rahim Hobbenaghi , Hasan Malekinejad
Department of Microbiology, Facutly of Veterinary Medicine, Urmia University, Urmia, Iran
Abstract:   (723 Views)
Background & objectives: Several studies have shown that pentoxifylline is an antioxidant and anti-inflammatory agent. Pentoxifylline (PTX), has been shown to exert protective effects on autoimmune disorders. The objective of the present study was to examine the effect of pentoxifylline on histopathology of pancreas in diabetic mice.
Methods: Diabetes was induced by multiple injection of low-dose streptozotocin (40 mg/kg/day for 5 consecutive days) in male C57BL/6 mice. After induction of diabetes, mice were treated with pentoxifylline (100 mg/kg/day i.p.) for 21 days. The nitric oxide levels were evaluated in spleen cell culture supernatant. Pancreases were isolated and stained by hematoxylin & eosin (H&E) and Gomori aldehyde fuchsin (GAF).
Results: Pentoxifylline treatment significantly inhibited the production of nitric oxide (p<0.05). In addition, PTX improved the pancreas tissue. It increased the mean diameter of islets and the number of islets and beta cells. (p<0.05).
Conclusion: These findings indicated that pentoxifylline might have a therapeutic effect against the autoimmune destruction of the pancreatic beta-cells during the development of STZ-induced type 1 diabetes in mice.
 
Keywords: Diabetes, Pentoxifylline, Nitric Oxide, Pancreas
Full-Text [PDF 273 kb]   (168 Downloads)    
Type of Study: article | Subject: General
Received: 2018/03/6 | Accepted: 2018/06/20 | Published: 2018/07/1
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Malekifard F, Delirezh N, Hobbenaghi R, Malekinejad H. Effects of Pentoxifylline on Nitric Oxide Levels and Histopathology of Pancreas in Diabetic Mice. J Ardabil Univ Med Sci. 2018; 18 (2) :204-214
URL: http://jarums.arums.ac.ir/article-1-1482-en.html


Volume 18, Issue 2 (summer 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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