[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Number 2 (summer 2017) ::
J Ardabil Univ Med Sci 2017, 17(2): 189-197 Back to browse issues page
Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne
Hasan Edalatkhah, Nazila Rahnema Tareghi, Saeeid Sadeghieh Ahari , Ali Nemati
3. Social determinants of Health Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (622 Views)
Background & objectives: Acne Vulgaris is a chronic inflammation of pilosebaceous glands. Some studies have indicated the significant decrease of linoleic acid in the sebum composition of the patients with acne. The aim of this study was to determine the probable therapeutic effects of linoleic acid on moderate acne.
Methods: In a double-blind randomized clinical trial, 40 women with moderate acne were divided into two groups, each group with 20 each with 20 samples. After recording the nutritional and demographic factors, the case group received, 100 mg oral doxycycline daily plus 3 gr conjugated linoleic acid and the control group received 100 mg doxycycline daily plus 4-3 oral paraffin capsules as placebo for one month. The number of acne lesions were counted before and after treatment and the mean of   Acne Severity Index (ASI) and Global Acne Grading System (GAGS) were determined for each group. The collected data were analyzed by SPSS software using chi-square, independent t-test and paired t-test.
Results: The mean age was 22.8±5.5, in the case group and21.7±5.1 in placebo group indicating no statistically significant deference (p=0.51). At the end of treatment there was no statistically significant deference between the two groups in decreasing acne (p=0.31). During the treatment, ASI reduced from 129.5±13 to 77±11.6 in the case group and from 132±18.6 to 67.5±11.6 in the placebo group, –but there was no statistically significant deference between the two groups (p=0.37).
Conclusion: It seems using 3 gr oral conjugated linoleic acid daily for 1 month has no effect on remission of acne.
Keywords: Acne Vulgaris, Conjugated Linoleic Acid, Placebo, Iran
Full-Text [PDF 175 kb]   (239 Downloads)    
Type of Study: article | Subject: General
Received: 2017/01/20 | Accepted: 2017/06/10 | Published: 2017/07/1
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Edalatkhah H, Rahnema Tareghi N, Sadeghieh Ahari S, Nemati A. Therapeutic Effect of Conjugated Linoleic Acid Supplementation on Moderate Acne. J Ardabil Univ Med Sci. 2017; 17 (2) :189-197
URL: http://jarums.arums.ac.ir/article-1-1376-en.html
Volume 17, Number 2 (summer 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.103 seconds with 799 queries by yektaweb 3501