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:: Volume 17, Number 1 (spring 2017) ::
J Ardabil Univ Med Sci 2017, 17(1): 81-89 Back to browse issues page
Effect of Alcoholic Extract of Rosa canina on Hepatic Tissue and Hepatic Enzymes Activity in Diabetic Rats
Seyedmahdi Banan Khojasteh, Elaheh Basirat , Farzam Sheikhzadeh, Homeira Hatami
Abstract:   (477 Views)

Background & aim: Nowadays because of difficulty in the supply and injection of insulin and blood sugar reducing drugs and considering the side effects of chemical drugs, researcher’s attention is drawn to using herbal medicines. Liver is one of the organs affected by diabetes in different functional aspects. The purpose of this research was studying the effect of Rosa canina extract on reducing the adverse effects and improving diabetes symptoms related to histophysiology, amount of biochemical serum factors and liver enzymes in male rats.

Methods: 32 male Wistar rats, weighed 200-220 gr, were divided into 4 groups. Diabetes was induced by intraperitoneal injection of STZ (60mg/kg). The period of experiments was 4 weeks. At the end of experiments, the rats were sacrificed and their serums were collected for measurement of liver enzymes. Also, histological sampling of liver was done. Statistical analysis was performed using analysis of variance (one-way ANOVA).

Results: The results of this study showed that treatment with ethanol extract of Rosa canina led to significant reduction of liver enzymes in the Rosa extract-treated groups in comparison with the diabetic group, indicating the protective effect of alcoholic extract of Rosa canina on liver tissue against diabetes-induced damages. In liver histopathology, a distinct fat change in the lobular center areas was created in the diabetic group. Pathological changes were not significant in the liver of the Rosa extract-treated groups; liver in this group was relatively healthier than in diabetic group.

Conclusions: Rosa extract improved this organ's function in STZ-induced diabetic rats by reducing serum biomarkers of liver pathology and reducing histological damages.

Keywords: Diabetes, Rosa canina, Hepatic Enzymes, Streptozotocin, Antioxidant
Full-Text [PDF 254 kb]   (272 Downloads)    
Type of Study: article | Subject: General
Received: 2016/11/3 | Accepted: 2017/02/26 | Published: 2017/03/30
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Banan Khojasteh S, Basirat E, Sheikhzadeh F, Hatami H. Effect of Alcoholic Extract of Rosa canina on Hepatic Tissue and Hepatic Enzymes Activity in Diabetic Rats . J Ardabil Univ Med Sci. 2017; 17 (1) :81-89
URL: http://jarums.arums.ac.ir/article-1-1317-en.html
Volume 17, Number 1 (spring 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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