:: Volume 17, Issue 1 (spring 2017) ::
J Ardabil Univ Med Sci 2017, 17(1): 58-68 Back to browse issues page
Effect of Hydroalcoholic Extracts of Truffle (Terfezia boudieri) Premedication on Improving Hepatic Factors in CCl4-induced Liver Injury in Male Rats
Yavar Mahmoudzade, Seyedeghbal Motavalibashi, Khaiam Bamdad, Eslam Zabihi , Hamid Sheikhkanloui Milan, Nasrin Hamidi
Abstract:   (4437 Views)

Background & objectives: Terfezia boudieri (TB) has more than 15 types of proteins, gallic acid, catechins, flavonoids, tannins and other compounds such as beta-carotene and linoleic acid. Some of these compounds have antioxidant and anti-hyperlipidemia effects. Therefore, this study aimed to examine the antioxidant and protective effects of this fungus on the liver injury induced by carbon tetrachloride.

Methods: 30 male Wistar rats were divided randomly into 5 groups (each group containing 6). Group 1 (normal control group) and group 2 (control CCl4) were given normal saline for 14 days. Group 3, 4 and 5 received 500, 1000 and 1500 mg/ kg doses of methanol extract of TB for 14 days, respectively before the injection of carbon tetrachloride. In the fourteenth day, all groups except group 1 were given 1.5 ml/kg of carbon tetrachloride (V / V 1: 1 dissolved in olive oil). Group 1, instead of carbon tetrachloride, received 1.5 ml/kg of olive oil on the fourteenth day.

Results: Injection of carbon tetrachloride in rats increased serum activity of ALT, AST, ALP and serum degrees of triglycerides, VLDL, LDL, HDL, total cholesterol, glucose, and reduced HDL and total antioxidant capacity (TAC); while pre-treatment with methanol extract of TB significantly reversed the changes.

Conclusion: The results of this study showed that methanol extract of TB can protect the liver against oxidants and free radicals produced by carbon tetrachloride metabolism.

Keywords: Terfezia boudieri, Carbon Tetrachloride, Antioxidants, Liver Injury, Rat
Full-Text [PDF 321 kb]   (1179 Downloads)    
Type of Study: article | Subject: General
Received: 2016/11/3 | Accepted: 2017/02/8 | Published: 2017/03/30


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Volume 17, Issue 1 (spring 2017) Back to browse issues page