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:: Volume 16, Number 4 (winter 2017) ::
Back to browse issues page J Ardabil Univ Med Sci 2017, 16(4): 432-440
Comparison of Repeated Measurement Design and Mixed Models in Evaluation of the Entonox Effect on Labor Pain
Nasim Karimi , Sara Ramazanjamaat, Nafiseh Saeidzadeh, Ghodratollah Roshanaei, Parisa Parsa
Student Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (768 Views)

Background & objectives: In many medical studies, the response variable is measured repeatedly over time to evaluate the treatment effect that is known as longitudinal study. The analysis method for this type of data is repeated measures ANOVA that uses only one correlation structure and the results are not valid with inappropriate correlation structure. To avoid this problem, a convenient alternative is mixed models. So, the aim of this study was to compare of mixed and repeated measurement models for examination of the Entonox effect on the labor pain.

Methods: This experimental study was designed to compare the effect of Entonox and oxygen inhalation on pain relief between two groups. Data were analyzed using repeated measurement and mixed models with different correlation structures. Selection and comparison of proper correlation structures performed using Akaike information criterion, Bayesian information criterion and restricted log-likelihood. Data were analyzed using SPSS-22.

Results: Results of our study showed that all variables containing analgesia methods, labor duration of the first and second stages, and time were significant in these tests. In mixed model, heterogeneous first-order autoregressive, first-order autoregressive, heterogeneous Toeplitz and unstructured correlation structures were recognized as the best structures. Also, all variables were significant in these structures. Unstructured variance covariance matrix was recognized as the worst structure and labor duration of the first and second stages was not significant in this structure.

Conclusions: This study showed that the Entonox inhalation has a significant effect on pain relief in primiparous and it is confirmed by all of the models.

Keywords: Repeated Measure Design, Mixed Models, Labor Pain Intensity, Entonox
Full-Text [PDF 162 kb]   (680 Downloads)    
Type of Study: article | Subject: General
Received: 2016/05/21 | Accepted: 2016/11/15 | Published: 2016/12/30
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Karimi N, Ramazanjamaat S, Saeidzadeh N, Roshanaei G, Parsa P. Comparison of Repeated Measurement Design and Mixed Models in Evaluation of the Entonox Effect on Labor Pain . J Ardabil Univ Med Sci. 2017; 16 (4) :432-440
URL: http://jarums.arums.ac.ir/article-1-1252-en.html
Back to browse issues page Volume 16, Number 4 (winter 2017)
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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