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:: Volume 17, Number 1 (spring 2017) ::
J Ardabil Univ Med Sci 2017, 17(1): 32-45 Back to browse issues page
The Preotective effects of Okra Powder (Abelmoschus esculentus) on Histological and Histochemical Changes of Pancreatic Beta Cells and Liver Tissue of Diabetic Rat
Naeim Erfani Majd, Zahra Soleimani , Ali Shahriari, Mohammadreza Tabandeh
Abstract:   (947 Views)

Background and Objective: Since Abelmoschus esculentus plant has many medical benefits, the present study aimed to investigate the therapeutic effects of Okra Powder (Abelmoschus esculentus) against high-fat diet fed-streptozotocin (HFD/STZ)-induced diabetic rats.

Methods: In this experimental study, 25 Wistar Albino female rats were randomly divided into 5 groups: I: control group; II: healthy rats receiving A. esculentus (200 mg/kg); III (HFD/STZ group): Rats fed with high-fat diet (HFD) (60% fat) for 4 weeks and then injected low-dose STZ (35 mg/kg); IV: diabetic rats receiving A. esculentus (200mg/kg) and V: diabetic rats receiving metformin (200 mg/kg). At the end of experiment, biochemical parameters, including Fasting Blood Glucose (FBG), insulin levels, Homa-IR index, ALT, AST and lipid profile were measured. Pancreas and Liver samples were removed, and 5-6 µ sections were prepared and stained by H&E and aldehyde fuchsin staining.

Results: All the biochemical parameters, except HDL-C and insulin, were increased in diabetic rats, while these parameters were decreased in Okra supplementation group compared to diabetic rats (p<0.05). Furthermore, Okra improved the histological impairments of pancreas and liver, including vacuolization, and decrease of β-cells as well as hypertrophy and vacuolization of hepatocytes in diabetic rats.

Conclusion: Okra powder improved biochemical parameters, liver structure and restoration of beta cells of pancreas in diabetic rats. Thus, it can be considered a complementary therapy to improve diabetic patients.

Keywords: Diabetes, Histomorphometry, Liver, Beta cells, Okra
Full-Text [PDF 460 kb]   (396 Downloads)    
Type of Study: article | Subject: General
Received: 2016/11/15 | Accepted: 2017/01/29 | Published: 2017/03/30
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Erfani Majd N, Soleimani Z, Shahriari A, Tabandeh M. The Preotective effects of Okra Powder (Abelmoschus esculentus) on Histological and Histochemical Changes of Pancreatic Beta Cells and Liver Tissue of Diabetic Rat . J Ardabil Univ Med Sci. 2017; 17 (1) :32-45
URL: http://jarums.arums.ac.ir/article-1-1313-en.html
Volume 17, Number 1 (spring 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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