[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 16, Number 4 (winter 2017) ::
Back to browse issues page J Ardabil Univ Med Sci 2017, 16(4): 452-463
Pathophysiology of Alzheimer’s Disease
Mohammad Amani
Department of Physiology, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (864 Views)

Alzheimer's disease (AD) is a common cause of dementia in elderly people that is accompanied by progressive cognitive decline and memory loss. The pathologic hallmarks of AD are synaptic and neuronal degeneration together with extracellular senile plaques containing amyloid-beta (Aβ) and the intracellular neurofibrillary tangles (NFTs) in the hippocampus and other cortical regions. Amyloid-beta peptide is believed to have a pivotal role in the pathogenesis of AD as a major component of the senile plaques. It acts as a trigger key of AD and is considered as the principal toxic factor in the pathogenesis of the disease. Accumulation of amyloid β protein (Aβ), a main component of the senile plaques, in the brain initiates a cascade of events that ultimately lead to neuronal dysfunction and cognitive deficits. Other proposed mechanisms for AD include impairment in cholinergic function, oxidative stress, inflammatory agents and glutamate-mediated excitotoxicity. AD is characterized neuropathologically by impaired cholinergic function, increased oxidative stress, neuroinflammation, neuronal cell death, synapses loss, cortical atrophy, deficiencies in steroid hormones and appearance of glutamate-mediated excitotoxicity.

Keywords: Alzheimer’s Disease, β-Amyloid Peptide, Tau Protein, Synaptic Function, Neurodegenerative Disorders
Full-Text [PDF 184 kb]   (847 Downloads)    
Type of Study: review article | Subject: General
Received: 2016/09/22 | Accepted: 2016/12/30 | Published: 2016/12/30
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Amani M. Pathophysiology of Alzheimer’s Disease. J Ardabil Univ Med Sci. 2017; 16 (4) :452-463
URL: http://jarums.arums.ac.ir/article-1-1254-en.html
Back to browse issues page Volume 16, Number 4 (winter 2017)
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.099 seconds with 783 queries by yektaweb 3392