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:: Volume 16, Issue 4 (winter 2017) ::
J Ardabil Univ Med Sci 2017, 16(4): 399-408 Back to browse issues page
Effect of Andrographolide‭ Extract on Blood Glucose and Lipid Profile in Rats with Secondary Iron Overload
َArash Mehri Pirayvatlo, Reza Alipanah-Moghadam , Mohammad Mazani, Farideh Manafi, Vadood Malekzadeh, Ali Nemati, Abbas Naghizadeh Baghi
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
Abstract:   (4580 Views)

Background & objectives: Iron overload is involved in the pathophysiology of many diseases including diabetes. In fact, the excess iron by creating free radicals makes damage to pancreas and leads to insulin resistance and diabetes. Andrographolide extract has hypoglycemic and antioxidant properties. This study has surveyed the effects of andrographolide on blood glucose and lipid profile in rats with secondary iron overload.

Methods: In this experimental study, 36 male Wistar rats were randomly divided into 6 groups: the healthy control group, secondary iron overload group, secondary iron overload groups treated with a dose of 3.5 and 7 mg/kg of andrographolide extract, and andrographolide groups treated with a dose of 3.5 and 7 mg/kg of extract. Iron and extract were injected for 6 and 12 days, respectively. Blood samples were taken for measurement of blood glucose and lipid profiles. Data were analyzed using ANOVA test.

Results: The pathological results of samples from liver of animals receiving iron showed that the iron was deposited in the liver tissues. Iron injection significantly increased blood glucose levels compared to healthy control group (p<0.05). In the iron overload group, andrographolide extract with a dose of 3.5 mg/kg or 7 mg/kg significantly decreased blood glucose levels (p<0.05). Iron injections did not increase the serum triglyceride and cholesterollevels. Injections of andrographolide extract with a dose of 3.5 mg/kg and 7 mg/kg, significantly decreased the cholesterol levels compared to iron receiving group (p<0.05).

Conclusion: Results of this study showed that the andrographolide with different doses may be effective in the treatment of diabetes by reducing serum glucose and cholesterol levels.

Keywords: Iron Overload, Andrographolide, Glucose, Lipid Profiles, Rat
Full-Text [PDF 227 kb]   (1154 Downloads)    
Type of Study: article | Subject: General
Received: 2016/10/16 | Accepted: 2016/12/1 | Published: 2016/12/30
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Mehri Pirayvatlo َ, Alipanah-Moghadam R, Mazani M, Manafi F, Malekzadeh V, Nemati A et al . Effect of Andrographolide‭ Extract on Blood Glucose and Lipid Profile in Rats with Secondary Iron Overload. J Ardabil Univ Med Sci. 2017; 16 (4) :399-408
URL: http://jarums.arums.ac.ir/article-1-1250-en.html


Volume 16, Issue 4 (winter 2017) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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