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:: Volume 18, Issue 2 (summer 2018) ::
J Ardabil Univ Med Sci 2018, 18(2): 215-229 Back to browse issues page
Evaluating the Effect of Ginger Extract on Azathioprine-Induced Renal Failure in Mature Female Rats
Zahra Godarzian , Ebrahim Hosseini Seyed
Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, Iran
Abstract:   (918 Views)
 
Background & objectives: Azathioprine is widely used for the treatment of autoimmune diseases. It has negative effects on the function of kidney. Therefore, considering the protective effects of ginger on nephrotoxins, the present study was conducted to investigate the effect of ginger on renal changes induced by azathioprine in rats.
Methods: In this experimental study, 56 female rats were divided into 7 groups including control, sham and 5 experimental groups receiving azathioprine (50mg/kg), ginger (200mg/kg), azathioprine plus ginger (200,100 and 50 mg/kg). In this study, ginger was administered by gavage and azathioprine intraperitoneally in 21 consecutive days. At the end, serum levels of urea, uric acid and creatinine were measured and the histological structure of the kidneys was examined. The results were analyzed by ANOVA and Duncan tests at significance level of p≤0.05.
Results: The results showed that azathioprine caused the destruction of structure along with cell necrosis, tubular degeneration, glomerular atrophy, urinary space enlargement, hyperemia and inflammatory cell infiltration in the renal tissue, as well as an increase in the serum level of urea, uric acid and creatinine at p≤0.05. However, simultaneous use of ginger and azathioprine reduced the serum levels of urea, uric acid, creatinine and improved the kidney structure compared to the azathioprine group.
Conclusion: The results showed that ginger had a protective effect on kidney tissue, due to its antioxidant properties, by inhibiting free radicals produced by azathioprine and decreasing the severity degradation effects of azathioprine on kidney tissue and function.
 
Keywords: Azathioprine, Uric Acid, Creatinine, Kidney, Urea, Rat
Full-Text [PDF 402 kb]   (220 Downloads)    
Type of Study: article | Subject: General
Received: 2018/01/21 | Accepted: 2018/05/20 | Published: 2018/07/1
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Godarzian Z, Hosseini E. Evaluating the Effect of Ginger Extract on Azathioprine-Induced Renal Failure in Mature Female Rats . J Ardabil Univ Med Sci. 2018; 18 (2) :215-229
URL: http://jarums.arums.ac.ir/article-1-1442-en.html


Volume 18, Issue 2 (summer 2018) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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