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:: Volume 13, Number 3 (autumn 2013) ::
J Ardabil Univ Med Sci 2013, 13(3): 287-296 Back to browse issues page
Prevalence of Co-Inheritance of Alpha-Thalassemia with Beta-Thalassemia and Beta-Hemoglobinopathy in Ahvaz City
Najmaddin Saki, Akbar Dorgalaleh, Zahra Kashani Khatib, Shaban Alizadeh , Fakher Rahim, Hamid Galehdari, Bijan Kaikhaei, Mohammad Pedram, Ali Dehghani Fard
Abstract:   (4461 Views)

  Background: Co-inheritance of hemoglobin gene defects is a rare important status that can lead to double heterozygote or homozygote with significant clinical manifestations. Such conditions can be observed in co-inheritance of alpha-thalassemia with beta-thalassemia or hemoglobinopathy. The aim of this study was to evaluate the prevalence of alpha-thalassemia with beta-thalassemia and hemoglobinopathy co-inheritance in a considerable number of Iranian.

  Methods: This descriptive study was performed on patients with abnormal hematological findings in favor of alpha-thalassemia, beta-thalassemia or beta-hemoglobinopathies. Patients with low MCV and MCH levels and high HbA2 (>3.5) and those with low MCV and MCH and normal or low HbA2 were candidate for molecular analysis for beta and alpha thalassemia respectively. Abnormal Hb electrophoresis was diagnostic criteria for molecular analysis of beta-hemoglobinopathies.

  Results: Study revealed that more than half of the patients with alpha-thalassemia affected simultaneously by beta-thalassemia and about thirty percent inherited beta-hemoglobinopathies. Among patients with beta-thalassemia, HbSCd6 (A-T) was the most common mutation and in alpha-thalassemic patients α 3.7 was the commonest mutation.

  Conclusion: Relatively high prevalence of co-inheritance of alfa-thalassemia with beta-thalassemia and hemoglobinopathies reflect the necessity of genetic consulting and molecular analysis in diagnosis of such conditions.

Keywords: Alfa-Thalassemia; Beta-Thalassemia; Hemoglobinopathy; Co-Inheritance
Full-Text [PDF 181 kb]   (1545 Downloads)    
Type of Study: article | Subject: Special
Received: 2012/11/15 | Accepted: 2013/02/18 | Published: 2013/09/23
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Saki N, Dorgalaleh A, Kashani Khatib Z, Alizadeh S, Rahim F, Galehdari H, et al . Prevalence of Co-Inheritance of Alpha-Thalassemia with Beta-Thalassemia and Beta-Hemoglobinopathy in Ahvaz City. J Ardabil Univ Med Sci. 2013; 13 (3) :287-296
URL: http://jarums.arums.ac.ir/article-1-105-en.html
Volume 13, Number 3 (autumn 2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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