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:: Volume 14, Number 3 (Autumn 2014) ::
J Ardabil Univ Med Sci 2014, 14(3): 217-228 Back to browse issues page
Synthesis and Surface Modification of Polycaprolactone Nanofibers for Tissue Engineering
Fereshteh Sharifi Ferdoey, Shiva Irani , Mojghan Zandi, Masoud Soleimani
Abstract:   (2464 Views)

  Background & objectives : T he main goal of tissue engineering is regeneration and restoration of damaged tissues and organs, besides being used in medicine . Scaffolds are the main segments for tissue engineering, and plasma surface modification is one of the modern methods used for surface modification on polymer scaffolds. The aim of this study was to evaluate the effect of nano-fibers with different densities on fibroblasts' behavior besides the plasma surface modification.

  Methods : Poly Ɛ-Caprolactone nano-fibers (PCL) were developed by an electro-spinning technique at different collecting times. These nano-fibers were then modified by oxygen plasma. Cellular attachment to the nano-fiber and their morphology were evaluated using scanning electron microscope (SEM) and cellular activities were also studied by 3-[4,5-dimethylthiazol- 2-yl]-2,5 diphenyltetrazolium bromide (MTT). Scaffold biocompatibility test was assessed using inverted microscope.

  Results : Scanning electron microscope images of nano-fibers showed that increase in time of spinning has significantly heighten fiber density, on the other hand plasma surface modification of nano-fibers had significant effects on their respective biocompatibilities. The result of cell culture showed that nano-fiber could support the cellular growth and replication by developing 3-dimensional topography.

  Conclusion : Our results showed that increase in time of spinning and using plasma surface modification of nano-fibers by oxygen plasma would result in providing surface with the highest similarity to the extracellular matrix.

Keywords: Nano-fiber, Surface Modification, Electrospun, Polycaprolactone
Full-Text [PDF 274 kb]   (1759 Downloads)    
Type of Study: article | Subject: Special
Received: 2013/11/11 | Accepted: 2014/05/9 | Published: 2014/09/28
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Sharifi Ferdoey F, Irani S, Zandi M, Soleimani M. Synthesis and Surface Modification of Polycaprolactone Nanofibers for Tissue Engineering. J Ardabil Univ Med Sci. 2014; 14 (3) :217-228
URL: http://jarums.arums.ac.ir/article-1-687-en.html
Volume 14, Number 3 (Autumn 2014) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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