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:: Volume 12, Number 4 (winter 2012) ::
J Ardabil Univ Med Sci 2012, 12(4): 363-372 Back to browse issues page
Accuracy of Diagnostic Tests for Helicobacter pylori Infection
Siyamak Khaleghi, Mahshid Talebi-Taher , Elnaz Salimi, Hoda Taghipour, Shahbaz Nekozadeh
Abstract:   (4389 Views)

  Background & Objectives: The diagnosisof Helicobacter pylori infection is based on invasive and non-invasive methods. The present study was carried out to evaluate the accuracy of three non-invasive and one invasive methods either separately or in combination for detection of Helicobacter pylori.

  Methods: A total of 108 dyspeptic patients older than 12 years who had not previously been treated for H. pylori infection were selected for upper GI-endoscopy. Histology was considered as a gold standard diagnostic test. Urea breath test, histologic examination and rapid urease test were done in endoscopy unit. Serology and stool anigen detection test were done in hematology unit of Nour Laboratory using ELISA Method.

  Sensitivity, specificity, positive and negative predictive values were calculated. The tests results were compared using the McNemar test.

  Results: According to histologic method, 56 patients had H. pylori infection. Sensitivities and specificities were 89% and 71% for the rapid urease test, 94% and 52% for serology, 90% and 82% for the urea breath test, and 46% and 80% for the stool test respectively. The most accurate combination test was rapid urease test and urea breath test.

  Conclusion: Rapid urease test and urea breath test in combination showed excellent diagnostic reliability.

Keywords: Helicobacter pylori; Dyspepsia; Histology; Urea Breath Test; Rapid Urease Test
Full-Text [PDF 293 kb]   (1889 Downloads)    
Type of Study: article | Subject: Special
Received: 2011/11/10 | Accepted: 2012/04/18 | Published: 2012/12/21
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Khaleghi S, Talebi-Taher M, Salimi E, Taghipour H, Nekozadeh S. Accuracy of Diagnostic Tests for Helicobacter pylori Infection. J Ardabil Univ Med Sci. 2012; 12 (4) :363-372
URL: http://jarums.arums.ac.ir/article-1-72-en.html
Volume 12, Number 4 (winter 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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