[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 12, Number 4 (winter 2012) ::
J Ardabil Univ Med Sci 2012, 12(4): 354-362 Back to browse issues page
The Role of NMDA Receptor on Spatial Learning and Memory Consolidation Rat Following Intra-Hippocampal Injection of Aqueous Extract of Leaves of Origanum (Origanum Vulgare L. ssp. viridis)
Tahereh Haghpanah, Vahid Sheibani, Mohammad Reza Afarinesh , Mousa Al Reza Hajzadeh, Khadijeh Esmail Pour Bezenjani, Yasamin Pahlavan
Abstract:   (10179 Views)

  Background & Objectives: I ntra-hippocampal adminestration of origanum (ORG) improves spatial learning of rats. T he aim of the present study was to investigate the possible mechanism for origanum extract on spatial learning and memory in the hippocampus.

  Methods : In this study 42 adult male Wistar rats were used . Animals were cannulated bilaterally in the posterior laterl of hippocampus. After the recovery period, the spatial learning and memory were assessed using Morris Water Maze (MWM). Saline, ORG (0.03μg/site) glutamate receptor antagonist MK801 (0.08, 0.2 and 0.4 μmol/site) and co-injected of MK + ORG was injected into the posterior lateral of hippocampus 20 minutes before the training and retrival sesions (for 5 consecutive days) (n=7).

  Results: The results showed that the intra-hippocampal injection of MK 801 significantly blocked the decreased distance and time of reaching (due to ORG injection) to find hidden platform of MWM (p<0.05). On the retrival tests, the average of time spent in the target area is reduced in the co-injected of MK801 + ORG group.

  Conclusion: The intra-hippocampal injection of aqueous extract oforiganum may improve working memory in rats through glutamate-dependent NMDA receptors.

Keywords: NMDA Receptors; Origanum; Hippocampus; Learning
Full-Text [PDF 278 kb]   (1796 Downloads)    
Type of Study: article | Subject: Special
Received: 2011/12/27 | Accepted: 2012/10/30 | Published: 2012/12/21
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Haghpanah T, Sheibani V, Afarinesh M R, Hajzadeh M A R, Esmail Pour Bezenjani K, Pahlavan Y. The Role of NMDA Receptor on Spatial Learning and Memory Consolidation Rat Following Intra-Hippocampal Injection of Aqueous Extract of Leaves of Origanum (Origanum Vulgare L. ssp. viridis). J Ardabil Univ Med Sci. 2012; 12 (4) :354-362
URL: http://jarums.arums.ac.ir/article-1-71-en.html
Volume 12, Number 4 (winter 2012) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
Persian site map - English site map - Created in 0.1 seconds with 803 queries by yektaweb 3501