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:: Volume 13, Number 1 (spring 2013) ::
J Ardabil Univ Med Sci 2013, 13(1): 102-109 Back to browse issues page
Comparison of Analgesic and Hypoglycemic Effect of Hexanic and Alcohlic Extract of Fenugreek Seed in Male Diabetic Rats
Sima Nasri, Mahmood Abedinzade , Masoumeh Jamal Omidi, Farzad Noursabaghi
Abstract:   (17965 Views)

 Background & Objectives: Diabetes mellitus is recognized with severe metabolic complications. Many herbal medicines have been recommended for treatment of diabetes. In this study, the antidiabetic and analgesic effect of hexanic and alcohlic extract Trigonella-foenum graecum was investigated in normal and streptozotocin-induced diabetic rats.

 Methods: Present study was carried out in 2011 at Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gr) were divided into six groups: control, type 1 diabetic, and 4 treat ed groups that received intraperitonealy hexanic and alcoholic extract of fenugreek (100, 200 mg/kg body weight) for 28 days. Two experimental models were used (acetic acid, and hot-plate tests) in order to characterize the analgesic effect. Blood glucose was measured with glucometer. Data analyzed with spss software 16 and one way ANOVA and Tukey tests. P<0.05 was statistically significant.

 Results: Compared to control rats, both of the aqueous - alcoholic and Hexan ic extract significantly reduced blood glucose level in all diabetics groups. This effect was stronger in groups that received Hexanic extract (p<0.05) . All groups received the aqueous - alcoholic and Hexan ic extract showed analgesic effect but this effect was more clear in the Hexanic 200 mg/kg group (p<0.05).

 Conclusion: Fenugreek extract possesses hypoglycemic , and analgesic effects .

Keywords: Diabetes Mellitus; Trigonella Foenum Graecum; Analgesic; Blood Glucose
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Type of Study: article | Subject: Special
Received: 2011/12/27 | Accepted: 2012/02/29 | Published: 2013/03/21
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Nasri S, Abedinzade M, Jamal Omidi M, Noursabaghi F. Comparison of Analgesic and Hypoglycemic Effect of Hexanic and Alcohlic Extract of Fenugreek Seed in Male Diabetic Rats. J Ardabil Univ Med Sci. 2013; 13 (1) :102-109
URL: http://jarums.arums.ac.ir/article-1-132-en.html
Volume 13, Number 1 (spring 2013) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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