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:: Volume 20, Issue 3 (autumn 2020) ::
J Ardabil Univ Med Sci 2020, 20(3): 328-339 Back to browse issues page
The Effect of 6 Week Resistance Training Program on Foxo1 Expression in Liver Cells and Glucose and Insulin Levels in Type 2 Diabetic Rats
Esmaeil Akbari , Saqqa Farajtabar Behrestaq , Babisan Askari
Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran.
Abstract:   (543 Views)
 
Background & objectives: Foxo1 is a transcription factor in insulin signaling in the liver. The function of Foxo1 is important in the ability of insulin to regulate hepatic glucose production and glucose homeostasis. The aim of this study was to determine the effect of resistance training program on Foxo1 expression in liver cells as well as glucose and insulin serum levels in male Wistar rats with type 2 diabetes.
Methods: The statistical population of this experimental study was 10-weeks old, male Wistar rats weighing 220±20 g (n=14). The studied rats were subjected to 6 weeks of high-fat diet and STZ injection for type 2 diabetes induction and then rats were randomly divided into two groups (control and resistance). The training group participated in a resistance training course for 6 weeks, 5 sessions per week, in the form of 4 sets and 5 repetitions per set, climbing a 26-step ladder to a height of one meter with a vertical slope of 80%. Finally, 48 hours after the last training session, fasting blood  glucose and insulin levels as well as Foxo1 expression level  in liver cells of both groups were measured and compared by independent t-test (a=%5).
Results: The resistance training improved fasting blood glucose compared to control subjects (p>0.001). the serum insulin levels were significantly increased (p=0.042) and Foxo1 expression significantly decreased in resistance group when compared with control subjects (p=0.023).
Conclusion: Based on these data, the decrease in glucose concentration in the exercise group can probably be attributed to the decreased expression of Foxo1 in hepatocyte cells in response to resistance training.
Keywords: Resistance training, Liver Cells, Serum Insulin, Type 2 Diabetes, Foxo1 Expression
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Type of Study: article | Subject: تربیت بدنی- فیزیولوژی ورزش
Received: 2020/09/26 | Accepted: 2021/01/19 | Published: 2021/05/10
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Akbari E, Farajtabar Behrestaq S, Askari B. The Effect of 6 Week Resistance Training Program on Foxo1 Expression in Liver Cells and Glucose and Insulin Levels in Type 2 Diabetic Rats. J Ardabil Univ Med Sci. 2020; 20 (3) :328-339
URL: http://jarums.arums.ac.ir/article-1-1921-en.html


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Volume 20, Issue 3 (autumn 2020) Back to browse issues page
مجله دانشگاه علوم پزشکی اردبیل Journal of Ardabil University of Medical Sciences
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